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Hernaez et al

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If you have a history of medication intolerance, severe allergies, or complex medical conditions, discuss combination therapy carefully with a clinician who can review your complete medical record

During the first 4 to 8 weeks of semaglutide therapy, most people experience gradual weight loss of approximately 1 to 2 pounds per week

If cost or other barriers are concerns, discuss with your healthcare provider about maintaining weekly dosing at a lower dose or switching to an alternative medication rather than extending the dosing interval

The long half-life means that even after stopping treatment, side effects can persist for several weeks