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In Arabidopsis thaliana , group I proteins that have C[P/G/S]Y[C/S] in the catalytic site are localized in the cytosol and plastids and are encoded by six genes

Gastrointestinal distress affects roughly 28% of users at higher doses, with nausea being the most commonly reported complaint

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Overall, treatment with Ag-NPs, nitric oxide synthase inhibitors, and cetirizine significantly modulated NO production, suggesting the involvement of the nitric oxide signaling pathway in the antipruritic effects observed in this study

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