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In an invited commentary on this study, the authors discussed the mixed literature on the impact of GLP-1 receptor agonists and risks of developing or progressing AMD, and raised some concerns regarding this latest research

[Abstract]2025;3(1):10

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Areas Requiring Further Investigation Further research is needed to clarify long-range receptor signaling behavior, tissue-specific pathway effects, molecular signaling durability, model-to-human translation, and how findings vary across study designs

1, Table 1, Extended Data Tables 1 and 2, and Supplementary Section 4) and substance-use disorders (via modulation of dopaminergic pathways of reward, impulse control and decision-making