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arsenic trioxide exerts dose-dependent dual effects on APL cells

GPx3 mRNA is also detected in other tissues, such as liver, heart, breast, lung 4 , skeletal muscle, pancreas, brain 5 , mature absorptive epithelial cells 6 and thyroid 7 , from where Gpx3 is secreted into the surrounding extracellular environment

The upregulated gene clusters are enriched in extracellular matrix components (collagens I and III, decorin, elastin), antioxidant defense systems (superoxide dismutase, glutathione-related enzymes), DNA repair pathways, and anti-inflammatory mediators including IL-10 and TGF-beta family members

The weekly schedule follows a 5-days-on, 2-days-off pattern

Acute stressor-selective effects on homocysteine metabolism and oxidative stress parameters in female rats

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