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Semaglutide, a GLP-1 receptor agonist, mimics the natural incretin hormone GLP-1 to enhance insulin secretion, slow gastric emptying, and increase satiety

Passive diffusion accounts for 1.2% of overall absorption, with little effect on bioavailability in patients with pernicious anemia or gastro-duodenal resection [49, 50]

Mixing reduces the number of daily injections

This knowledge also explains why oral B12 supplementation may be ineffective in intrinsic factor deficiency, requiring alternative routes like sublingual, nasal, or injectable B12 to bypass the intrinsic factor-dependent absorption pathway

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