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To limit computational costs, only cells profiled with the Smart-seq platform (73,000 cells) were used

Furthermore, evidence indicates that NRF2 can transcriptionally upregulate CHAC1, as observed in ferroptosis-resistant melanoma cells where CHAC1 induction occurs independently of ER stress ( de novo GSH synthesis (Kre et al., 2023)

26 Through mediating the post-translational modification dependent on NAD + , sirtuins modulate the adaptation to the altered cellular energetic status, especially the activation of oxidative metabolism and stress resistance in mitochondria in various physiological or pathological conditions

MDS plot showed expected, tight clustering among controls, but high biological variability across the CD samples

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