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Impaired glucose tolerance has been reported in 21-64% at diagnosis and diabetes mellitus in 20-47% ( Figure 1 Table 1 Metabolic effects of insulin and alterations in Cushings disease and acromegaly

Poor glycemic control can affect kidney function over time, while some diabetes medicationsincluding insulin (which can cause edema regardless of formulation, particularly after initiation or dose intensification) and thiazolidinedionesare known to cause fluid retention

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"Clients that cover weight loss today, we're expecting that they can see, you know, up to almost 20% a reduction [in] their costs with this updated arrangement that we've been able to get with Lily and Novo, " said Carter, adding that Evernorth was able to get better pricing while maintaining coverage for both drugs

Diabetologia (1995) 38(7):7536