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Unlike single or dual-action treatments, Retatrutide targets the GLP-1, GIP, and glucagon receptors all at once

The latest prescription drugs, like Zepbound, Wegovy and Saxenda are approved for chronic (long-term) weight loss and come as subcutaneous (under the skin) injections

Patients with certain genetic profiles may require slower dose escalation or more frequent blood pressure monitoring

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Cell Mol Neurobiol

Common Side Effects The most frequently reported side effects of GLP-1 medications include: Nausea (most common, especially during dose escalation) Vomiting Diarrhea Constipation Abdominal pain Decreased appetite Fatigue Headache These side effects are typically most pronounced during the initial weeks of treatment and when doses are increased