In interim data presented this spring, investigators found that patients experiencing medication-driven weight loss showed a significant reduction in adipose-derived stem cells cells involved in tissue regeneration and structural support.[2] That may help explain why some people notice: hollow cheeks and temples, crepey or loose skin, increased dryness, more visible wrinkles, sagging around the jawline, and skin that suddenly looks tired or deflated
Longer exposure means the system requires more time to re-establish baseline appetite and digestive signaling
Retatrutide shows 25% weight loss for women
Build lasting habits: Were not about quick fixes
These mechanisms are the basis for the highly efficacious GLP-1 analogues that today offer safe and effective treatment in millions of people living with obesity
Nausea is the most commonly reported adverse effect, occurring in approximately 15-20% of patients taking Ozempic and up to 44% of patients taking Wegovy at the 2.4 mg dose during clinical trials