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It is worth noting that GLP-1 receptor distribution is not the same in rodents and humans, and that has big implications for how we interpret preclinical studies and whether they will translate to people

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GLP-1 receptor activation suppresses appetite by signaling to the hypothalamus that the body has adequate nutrition

Junho, C

This prior adaptation means you can tolerate a higher starting dose without the full spectrum of GI side effects that a GLP-1 naive person would experience

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