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Copper has a complex role in oxidative biology participating in both prooxidant chemistry (where free or weakly bound copper can catalyze damaging reactive-oxygen-species generation) and antioxidant chemistry (as the cofactor of Cu/Zn superoxide dismutase)

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TB-500 is a synthetic analog of thymosin beta-4 (TB4) , a protein found in most human and animal cells

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If you have ever reacted to copper jewellery, copper cookware, or supplements containing copper, the topical ingredient is likely to cause the same response