Measuring the entire endocrine panel is complex, expensive, and can introduce a lot of noise
by contrast, antagonizing NMDA receptors in the hypothalamus has been linked to a reduction in food intake and a decrease in body weight 8
Side effects are usually minor and short-lived
Retrieved from Kraftson, A., & Griauzde, D
Signs you should slow down the titration Extend your stay at the current dose by 2-4 additional weeks if you experience any of the following at the end of a standard 4-week period: Nausea persisting beyond the first 7 days after the last dose increase Vomiting more than twice per week Diarrhea lasting more than 10 days at the current dose Significant fatigue or weakness that does not improve with adequate nutrition and rest Weight loss exceeding 1.5% per week (too-rapid loss increases gallstone risk and muscle loss) Slowing the titration is not failure
Of course, regulatory approval will hinge on demonstrating not just efficacy but long-term safety (perhaps via an outcomes trial to show no increase in cardiovascular events, similar to requirements for diabetes drugs)
