Food and Drug Administration (FDA) has so far approved three products containing semaglutide
Phase 2 trial results (48 weeks, adults with obesity): 1 mg dose: 7.2% body weight loss 4 mg dose: 12.9% body weight loss 8 mg dose: 17.3% body weight loss 12 mg dose: 24.2% body weight loss Placebo: 1.6% body weight loss Phase 3 TRIUMPH-4 results: 9 mg dose: 20.0% body weight loss (22.9 kg / 50.5 lbs) 12 mg dose: 23.7% body weight loss (27.2 kg / 60.0 lbs) Placebo: 4.6% body weight loss In a separate phase 3 analysis, retatrutide at the highest dose achieved up to 28.7% weight loss
These findings were summarised in a recent meta-analysis (Reference Raman, Avendano and Chen7) looking at the effects of flavan-3-ols intake on cardiometabolic risk factors which included 157 RCTs
The higher concentration of pheomelanin makes the skin brighter
Randomized, placebo-controlled trials are the gold standard for demonstrating efficacy
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