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This study suggests why mindfulness might help with conditions involving rumination - the practice changes the brains connectivity so that the usual default mode chatter is quieter

Sympathetic overactivity also contributes by increasing vascular resistance, promoting cardiac remodeling, and worsening hypertension and heart failure [35]

J Obstet Gynaecol Res (1996) 22(1):7983

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They should never be utilized in research models involving active cancerous tumors, as angiogenesis can theoretically accelerate tumor growth by supplying blood to the malignant tissue