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The key principle is based on the specific binding between the GST tag and glutathione, which allows for the isolation of the bait protein and its interaction partners

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Pataer A, Guo C, Shao R, Correa AM, Behrens C, Fang B, Roth JA, Wistuba II, Swisher SG

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Targeting glutamine metabolism in breast cancer with aminooxyacetate