The most frequently reported side effects of tirzepatide are gastrointestinal in nature, occurring in a substantial proportion of patients during clinical trials
But biological plausibility is not the same as clinical proof
Retatrutides 28% nausea rate at the highest dose compares favorably to Ozempics 44% rate
37 19381943.( 10.2337/dc13-2618) [DOI] [PubMed] [Google Scholar] 27.Ceriello A, Novials A, Ortega E, Canivell S, La Sala L, Pujadas G, Esposito K, Giugliano D, Genovese S
Kardie Tobb, DO, MS, FASPC, FACC, a boardcertified preventive cardiologist and the medical director for the Cone Health HeartCare Womens Heart Health and Cardio-Obstetrics Clinic, explains some of the most common reasons why GLP-1s may not deliver the results youre hoping for, including: You need a higher dose and have not yet reached a therapeutic dose as determined by your doctor High intake of liquid calories , including alcohol and ultra-processed foods Not getting enough protein , which can leave you persistently hungry and makes it harder to feel full Advanced diabetes or insulin resistance Taking other medications such as sulfonylureas, which lower blood sugar but can lead to weight gain Not adhering to your dosing schedule , such as inconsistent weekly injections or missed doses Differences in gut hormones or genetics And just because your GLP-1 isnt working immediately doesnt mean it wont work for you
GLP-1 receptor agonists slow gastric emptying, which may cause stomach contents to remain present longer than expected despite appropriate fasting
