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Crespel, A., De Boisvilliers, F., Gros, L

Using multi-omics analysis combined with human ovarian pathology and clinical biopsy, they found that glucose metabolism and tricarboxylic acid cycle (TCA) cycles changed in the granulosa cells of aging patients

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The mode of action of -carotene in murine melanoma cells may conclude the blockage of Bcl-2, p53, and caspase-3, which then stimulates apoptosis and potency of -carotene upon tumor-specific angiogenesis, due to which tumor growth is affected

Major exogenous causative factors are infections, intake of particular substances, and radiation, while endogenous factors are mainly sex and genetic disposition (Figure 1)

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