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For the dietary intervention studies (Table 2, n = 6 publications representing 5 independent trials), data extraction included study design and quality indicators, sample characteristics and diagnostic criteria, details of the intervention such as diet type, duration, and adherence monitoring, outcome measures including opioid peptide levels and behavioral assessments, and reported results along with effect sizes

The common methods are the plate count, membrane filtration, the multiple-tube method, and enzyme-based presence-absence tests

doi: 10.18632/oncotarget.20036 288 LiuYRYangLXuQQLuXYMaTTHuangCet al

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(Its not clear if the peptides were responsible for the symptoms.) Considering the skin-darkening peptide melanotan II (sometimes called the Barbie peptide)