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Another compound, HPP971, elevated reduced GSH levels and protected human astrocytes from H 2 O 2 -induced cell death in vitro and induced HO1 expression in a murine EAE model of MS, attenuating loss of motor functions [304]

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The loop structure C-terminal to helix 2 is predicted to be different for ROXY9 and GRXC2 To evaluate structural differences between ROXY9 and GRXC2, we compared the respective predictions according to AlphaFold (Fig

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