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As the primary factors for the reduced anticancer effect 1) the reduced delivery and uptake of the anticancer agent, 2) the need for the conversion of molecular oxygen (O 2 ) into reactive oxygen species (ROS), 3) the preferred therapeutic effect against highly proliferating cells, which is reduced under hypoxic conditions, or 4) adaptation of the cancer cells by promoting cell survival and upregulating certain resistance pathways, has been suggested 1,2,3,4,5

Lozupone, M

Implications & Mechanisms The fact that Reta slowed tumor growth without causing weight loss suggests it may act through: Direct effects on tumor cells and/or Modulation of immune responses or metabolism inside the tumor microenvironment

This flexibility is useful for specialized research applications that require specific compound characteristics or delivery formats

No difference in HDL cholesterol was observed between the groups