Model building and refinement The structures of the LSN3160440GLP-1GLP-1RG s (PDB: 6VCB), GLP-1GLP-1RG s (PDB: 6X18), and RGT1383GLP-1RG s (PDB: 6B3J) were used as an initial template for model building of compound 2, compound 2 plus GLP-1, and compound 2 plus LY3502970 bound complexes, respectively
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575 Similarly, the loss of mitochondrial complex I leads to a decrease in the ratio of NAD + /NADH and can inhibit the activity of Sirt3, thereby enhancing the protein acetylation and mPTP sensitivity
2021;131(20):e151800.
Fielding, R