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One reason tirzepatide became so popular is because the weight loss results seen in studies were significantly greater than older GLP-1 medications
Standard therapeutic doses for diabetes typically range from 0.5 mg to 2 mg weekly for semaglutide (with Wegovy dosing up to 2.4 mg weekly for obesity), though lower doses are used during initial titration to minimize gastrointestinal side effects
Increases in calcitonin levels have been observed in some patients, though the clinical significance remains uncertain
This can mean more weight loss, better blood sugar control, and stronger health protection
Patients receive support with lifestyle recommendations such as staying hydrated, eating balanced meals, and monitoring how their body responds after the first dose
N Engl J Med 2023;389:222132.ArticlePubMed 73
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