Its highest expression is on the luminal surface of the proximal tubules in the kidney, whilst the bile ducts, bile canaliculi, and endothelial cells of the nervous system capillaries also have high expression (Shiozawa et al., 1989
The peptide is based on the native GIP sequence with modifications that confer GLP-1R agonist activity
10.1542/peds.2007-0391 67 HanV
Pro tip: Works best alongside anti-inflammatory foods (like omega-3s, leafy greens) and consistent resistance training that enhances insulin sensitivity
Not all the news was good the study also found an increased risk of gastrointestinal disorders, hypotension, syncope, arthritic disorders, nephrolithiasis, interstitial nephritis, and drug-induced pancreatitis
Meanwhile, the intake of cannabis has itself been associated with increased prevalence of depressive disorders (Bovasso, 2001)