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Bottom, interactions between PF 06882961 (left) and OWL-833 (right) with the GLP-1R as determined by Ligplot+
The chemical properties of human amylin predisposes the hormone to aggregate and form amyloid fibrils, which are often found in pancreatic islets of individuals with type 2 diabetes and possibly contribute to beta cell destruction (62)
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If weight loss hasn't begun by week 8, discuss with your PlexusDx provider whether your dose has reached therapeutic levels, whether lifestyle factors need adjustment, or whether genetic testing might reveal barriers to response
This may include dietary adjustments, lifestyle changes, medical treatments, and weight loss injections
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