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Inhibition of Glutamate cysteine ligase depletes neuronal glutathione, elevates glutamate and increases excitatory neurotransmission Glutamate cysteine ligase (GCL) is the rate limiting step for glutathione synthesis, and utilizes glutamate as a substrate

( b, f, k ) Euler angle distribution histograms of the particles used in reconstructions for the consensus map (B), conformer 1 (f), and conformer 2 (k)

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\Insulin Sensitivity: Enhances insulin action and glucose uptake in tissues