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So its effects on pregnant women are unknown

Acetaminophen-induced oxidative stress results in lipid peroxidation, oxidation of protein thiols, mitochondrial injury, altered calcium homeostasis and DNA damage 43

PEGylation improves molecular stability and resistance to enzymatic degradation, allowing researchers to observe extended peptide signaling dynamics in controlled experimental environments

Downregulation of the receptor also occurs through dephosphorylation by several protein tyrosine phosphatases and protein inhibitor of activated STATs (PIAS)