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While these suggest a favorable profile at moderate doses, large-scale human clinical trials haven't been conducted

A larger number remain investigational compounds supported by limited clinical data

B12 is a water-soluble vitamin, meaning any excess is quickly flushed out through the urine

Lipid peroxidation assay was performed by determining the reaction of malonaldehyde with two molecules of 1-methyl-2-phenylindole at 45C (Gasparovic et al ., 2013)