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Melatonin pre-treatment downregulates the expression of PINK1 and Parkin proteins, upregulates the levels of Tom20 and COXIV proteins, and inhibits Ropivacaine-induced mitochondrial hyperautophagy, which in turn reduces the Bax/Bcl-2 ratio and caspase-3 expression, and inhibits apoptosis in PC12 and HT22 cells (Zeng et al., 2022)

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