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[DOI] [PMC free article] [PubMed] [Google Scholar] 79.Casciola-Rosen L., Thiemann D.R., Andrade F., Trejo-Zambrano M.I., Leonard E.K., Spangler J.B., Skinner N.E., Bailey J., Yegnasubramanian S., Wang R., et al

Where the Science Still Has Gaps Several questions remain unresolved: optimal dosing for therapeutic applications long-term systemic safety standardized clinical protocols large randomized human trials These gaps highlight the difference between promising experimental science and established clinical practice