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The compound has high potency and affinity for hMC4R (EC 50 = 0.27 nM) with reduced activity on hMC1R (EC 50 = 5.8 nM) and hMC3R (EC 50 = 5.8 nM) ( Table 1 ) ( 50 = 0.053 nM) and the hMC3R (EC 50 = 0.82 nM) ( Table 2 ) ( s pathway (79)

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