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Fiber from a regular diet is directly associated with fecal short-chain fatty acid concentrations in the elderly

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Healthcare providers may recommend temporarily reducing the semaglutide dose or increasing monitoring

Dose Adjustment : If fatigue is severe or persistent, healthcare providers may consider slowing the dose-escalation schedule (FDA labeling allows for flexible titration with 2.5 mg increments no more frequently than every 4 weeks) or maintaining a lower maintenance dose that balances therapeutic benefit with tolerability

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Researchers observed similar heart health improvements in participants with a body mass index (BMI) of 27 the average BMI for adults in the UK as in those classified with the highest BMIs