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Your thirst signal may be reduced on GLP-1s

These receptors are responsible for mediating the biological effects of GLP-1, including appetite suppression and insulin regulation

Craving reduction varies widely and is not guaranteed

PMID: 40094000 Retatrutide purchased from MedChemExpress

Participants receiving the highest dose (12 mg weekly) achieved a mean body weight reduction of approximately 24% from baseline at 48 weeks a figure that, whilst encouraging, should be interpreted with caution as cross-trial comparisons with approved agents are not methodologically robust in the absence of head-to-head data

The 10mg vial is ideal for the Phase 1 starting dose