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Clinical manifestations of hematologic and oncologic disorders in patients with Down syndrome

General Characteristics of the Participants A structured questionnaire was administered to ascertain general aspects [e.g., age, occupation, marital status, residence, substance use, reasons of substance use (e.g., for pleasure, social use, nervousness, or sadness), physical activity], academic aspects, and stressors in school

Excited to share that the final chapter of my PhD thesis is now published in the Journal of Medicinal Chemistry ( Although reactivity with glutathione is commonly used as a proxy for metabolic liability of covalent drugs, in this work we show that the intrinsic reactivity (electrophilicity) of covalent warheads is not a reliable predictor of their in vivo metabolic susceptibility