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The hallmark clinical features of PD include resting tremor, muscle rigidity, bradykinesia, and postural instability, all of which significantly impact patients quality of life (Heikkila et al., 1989)

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Other lung diseases Nrf2 is implicated in the pathogenesis and progression of various pulmonary diseases, including pulmonary fibrosis (PF), high-altitude pulmonary oedema [107], plateau pulmonary oedema, and chronic obstructive pulmonary disease (COPD) [109]

Receptor-independent effects of melatonin in CRC: Many of melatonins reported anticancer effects in CRC, including ROS modulation, regulation of MAPK/mTOR pathways, HDAC4 nuclear translocation, microRNA modulation, inhibition of NF-B and HIF-1 activity, and antioxidant enzyme activation, do not directly affect MT1/MT2 receptors and appear to be receptor-independent