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This is why semaglutide is generally considered a long-term medication rather than a short-term solution

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Plant Physiol 142:13641379 Noshi M, Yamada H, Hatanaka R, Tanabe N, Tamoi M, Shigeoka S (2017) Arabidopsis dehydroascorbate reductase 1 and 2 modulate redox states of ascorbateglutathione cycle in the cytosol in response to photooxidative stress