3 Introduction/background: a novel dual incretin analog Despite historical research stating GIP did not assist in lowering blood glucose even with supratherapeutic levels, the success of GLP-1 RAs has led to the approval of a novel GLP-1/GIP RA, tirzepatide [42]
Pills lose up to 40% effectiveness to digestion and require special administration (empty stomach, 30 minutes before food)
Clinicians must screen for contraindications before initiating therapy, which include personal or family history of medullary thyroid carcinoma or MEN 2, and hypersensitivity to tirzepatide
If a drop of blood appears, use gentle pressure with clean gauze or a cotton pad
The widely repeated claim that GLP-1 symptoms always begin within 24 to 72 hours is too precise
Can food supplements and supplements still be taken after the best-before date has expired