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Lipopolysaccharide-activated microglia cause BBB dysfunction, characterized by lower trans-endothelial electrical resistance and altered expression of tight junction proteins [56]

Biochem Biophys Res Commun 405 , 173179, doi: 10.1016/j.bbrc.2011.01.002 (2011)

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Alleviation of TBI-Induced Inflammation Neuroinflammation is an important pathological cause of secondary TBI, which induces instant activation of innate immunity in brain tissue associated with impairment of the BBB, increases water content in the brain, and promotes the secretion of excitatory neurotransmitters, causing an imbalance in ion homeostasis and apoptosis, eventually leading to brain dysfunction [71]

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