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Literature was searched in PubMed and Web of Science up to March 31, 2026, using combinations of terms including GLP-1 receptor agonist, semaglutide, liraglutide, tirzepatide, obesity, taste, flavour, dysgeusia, food preference, dietary intake, eating behaviour, appetite, satiety, food reward, craving, liking, wanting, and interoception. Studies were considered relevant if they addressed gustatory sensory function, hedonic food evaluation, food preference, dietary intake, cue-related food motivation, interoceptive modulation, or reward-related neural processing
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Venturella G, Ferraro V, Cirlincione F, et al
2025 Jan 23;188(2):412-429.e27
After 52 weeks, participants who took 36 milligrams of orforglipron saw a key blood sugar marker reduce by nearly 2 percent, while those who received 14 milligrams of oral semaglutide saw levels drop by nearly 1.5 percent
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