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This fact has significant consequences for oral bioavailability (transport into enterocytes or active excretion into the intestinal lumen), hepatic metabolism (transport into hepatocytes for enzymatic metabolism and for excretion into bile), and renal clearance (transport into proximal tubular cells and excretion into the tubular lumen)

Widemann 2006)

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James LP, Hinson JA, Polson J, Larson AM, Fontana RJ, Lalani E, Munoz S, Shakil AO, Lee WM