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Large doses of vitamin D can be harmful, even though there may not be immediate symptoms of toxicity

39 In addition, patients with extremely high serum acetaminophen concentrations (above a parallel line coinciding with a 4-hour postingestion concentration of 300 micrograms/mL or 2000 micromoles/L) were observed to have a 90% risk of developing hepatotoxicity

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Phase 3 trials of tirzepatide did not exclude participants taking antioxidant supplements, and subgroup analyses showed no difference in adverse events or efficacy between supplement users and non-users

A price reduction is required for semaglutide to be considered cost effective at a $50,000 per QALY threshold

Multiple reviewers describe starting at very low doses (0.04 ml) and taking months to reach therapeutic levels, all while being charged $199-299/mo