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High frequency of skin-homing melanocyte-specific cytotoxic T lymphocytes in autoimmune vitiligo
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To elucidate this, mice that were deficient of hepatic igf1 using the CreloxP system were generated (303)
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Also, some medical providers are more confident that injectable forms are more efficacious than oral alternatives
On a therapeutic note, some microbiota-targeted treatments have reduced protein aggregates in models: long-term broad-spectrum antibiotics reduced A deposition and microglial reactivity in an AD mouse model, and recolonization with a simplified microbiota reversed some of these effects, indicating that specific microbial communities can either exacerbate or ameliorate protopathic cascades [102]
