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Some patients experience anxiety as a less common but documented side effect, likely related to appetite suppression affecting energy intake and blood sugar patterns

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38 Another study using glimepiride or metformin as monotherapy observed changes in serum sialic acid in patients with T2DM over a period of 12 months

Role of insulin-like growth factor-1 (IGF-1) pathway in the pathogenesis of Graves orbitopathy

These medications slow gastric emptyinga key mechanism for blood sugar control and appetite suppressionwhich may theoretically increase reflux risk