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We also thank Alexei Rohou, Axel Brilot, Tamir Gonen, and Meghna Gupta for helpful discussions on cryo-EM map refinement and model building, and members of the Tomasiak lab and Robert Stroud for helpful discussions and critical reading of this manuscript

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Concomitant medicines : Clinicians should review all concurrent medications, particularly insulin or sulfonylureas, given the potential for hypoglycaemia with incretin-based agents