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The taper follows the escalation schedule in reverse: 12mg to 8mg to 4mg to 2mg, then stop
This shift indicates a broader trend among insurers, where approximately 60% of plans include medications for obesity-related conditions, though stringent criteria often apply
Exp Mol Med 54 , 377392 (2022)
Authors complied with the ARRIVE guidelines
The counter-argument is that mechanistic evidence is strong, multiple lines of clinical evidence converge, and the risk profile at microdose levels is favorable
In these patients, routine serum Vitamin B 12 measurements at two- to three-year intervals may be useful
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