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320 Peripheral nerves develop insulin resistance in T2DM

Others find PMS worse, particularly if theyre newly ovulating after a period of anovulation

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JAMA Ophthalmol 2023;141:8:747-754

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What research does show: Greater average weight reduction at higher doses Greater HbA1c reduction at higher doses Increased side effects with dose escalation What research does not yet establish: Whether ultra-low doses maintain meaningful long-term weight reduction Whether microdosing produces comparable metabolic outcomes Whether indefinite low-dose therapy is effective for maintenance Much of the online discussion is anecdotal rather than trial-based