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The selectivity arises from the peptides structure representing only the lipolytic region of growth hormone without the receptor-binding domains responsible for broader effects
The Forkhead box O (FOXO) transcription factors (FOXOs) control diverse cellular functions, such as metabolism, longevity, and cell death
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Duration of effect is how long the downstream response lasts, which can be far longer than the half-life if the peptide sets off a cascade that keeps running on its own
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Critical role of reactive oxygen species (ROS) for synergistic enhancement of apoptosis by vemurafenib and the potassium channel inhibitor TRAM-34 in melanoma cells
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