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Common clinical manifestations of MC4R variants PHARMACOLOGICAL THERAPIES FOR MC4R -DEFICIENT OBESITY While lifestyle modifications such as dietary restriction and physical activity provide only modest weight loss benefits, large-scale cohort studies have demonstrated that strict conventional interventions often result in suboptimal weight reduction outcomes among MC4R variant carriers [39-42]

Impaired endothelial function in arterial hypertension and hypercholesterolemia: potential mechanisms and differences

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