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The practical rule is simple

Mild injection-site soreness or light-headedness can occur

The most common side effects people experience are varying types of gastrointestinal (gut) distress

The American Diabetes Association Standards of Care do not include berberine in evidence-based treatment algorithms, and patients with type 2 diabetes should not discontinue prescribed medications in favor of supplements without medical supervision

Taurine: Amino acid which improves metabolism and is often used as a muscle building and athletic performance supplement

Glutathione, a potent endogenous antioxidant compound, is a likely mediator of these effects