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However, when intracellular levels of labile Fe2+ become excessively high, it reacts with hydroxyl radicals via the Fenton reaction, triggering a surge in reactive oxygen species (ROS) production and the accumulation of lipid peroxidation

Although this seems promising, there is very little evidence supporting topiramates effectiveness, and it does have adverse effects in the brain such as paresthesias (abnormal burning or prickling sensation) [23]

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3 Molecular functions of ChaC1 ChaC1 and its homologues function as -glutamyl cyclotransferases (GCTs) that specifically degrade glutathione