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To test whether this newly identified L1FnIII-2 interaction is functionally important for receptor activation, we introduced multiple mutations in the L1 hairpin of IGF1R (K164A, T166A, N169A, and Y171A), deleted the entire L1 hairpin (163174), or replaced this L1 hairpin with a short GSGS loop (163GS) to disrupt this interaction

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This sustained presence of GLP-1 prolongs its beneficial effects on appetite, blood sugar, and satiety

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Preclinical research has demonstrated that GLP-1 receptor activation may confer neuroprotective effects through multiple mechanisms